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Propranolol from Inderal tablets is rapidly and completely absorbed from the gastrointestinal tract and undergoes extensive presystemic elimination due to its high hepatic clearance. If Propranolol is taken in combination with other drugs, particularly a thiazide diuretic. Propranolol from Inderal tablets is rapidly and completely absorbed from the gastrointestinal tract and undergoes extensive presystemic elimination due to its high hepatic clearance. If Propranolol is taken with calcium channel blockers such as verapamil, nifedipine or diltiazem, there may be an increased risk of slow heart rate.
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