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Because of its broad spectrum of action, Levofloxacin is frequently prescribed empirically for a wide range of infections before the specific causal organism is known. Some medications will cause health effects and serious reactions when taken with Levaquin. Taking Levofloxacin with an acidic beverage such as a cola drink may increase its absorption. Side effects of Levaquin include tendon ruptures and other tendon type of injuries. Levaquin can make your skin sensitive to the sun photosensitivity and the light from sunlamps and tanning beds.